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Cost-Effectiveness Analysis of Thermotherapy Versus Pentava-Lent Antimonials for the Treatment of Cutaneous Leishmaniasis

Serie

  • Documentos de Trabajo CIEF

Resumen

  • The treatment of cutaneous leishmaniasis is toxic, has contraindications and a high cost. Objective: To estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. Methods: Effectiveness was the proportion of healing, and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing was conducted. Average and incremental cost-effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety and costs was determined through sensitivity analyses. Results: The total costs were $66,807 with Glucantime and $14,079 with thermotherapy. The therapeutic effectiveness rates were 64.2% for thermotherapy and 85.1% for Glucantime. The average cost-effectiveness ratios ranged between $721 and $1,275 for Glucantime and between $187 and $390 for thermotherapy. Based on the meta-analysis thermotherapy may be a dominant strategy. Conclusion: The excellent cost-effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment.

fecha de publicación

  • 2018-02

Líneas de investigación

  • Analysis
  • Antimony
  • Colombia
  • Cost-Effectiveness
  • Cutaneous
  • Gluconate
  • Leishmaniasis
  • Sodium
  • Thermotherapy

Issue

  • 16361