This paper analyzes the determinants, effects and costs of domestic violence (DV) against women and children in Colombia. The most relevant factors that explain the occurrence of DV in a household are suffering from DV as a child and living with someone that frequently and excessively consumes alcohol. DV against women increases their probability of unemployment by 6.4 percentage points, lowers their earnings by approximately 40% and worsens their health. DV against children negatively affects their health, school attendance and academic attainment. It is estimated that at least 4.2% of Colombian GDP is lost due to indirect costs of DV.