Latin America is facing trying times. Economies across the region have witnessed an unprecedented increase in unemployment and the incidence of poverty, and gender disparities have widened. The design and implementation of social programs and policies to mitigate the impacts of the pandemic have been at the core of the public policy and academic debates in recent months. The 2021 LACEA-LAMES annual meeting is an ideal forum to reflect and discuss how our region can best navigate these difficult times without losing sight of other significant economic challenges as the pervasiveness of inequality, the effects climate change, and the future of work.